Complete list of publications:

https://www.ncbi.nlm.nih.gov/myncbi/16o7gUz8_0CQn/bibliography/public/

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Bettaieb A, Averill-Bates DA. Thermotolerance induced at a mild temperature of 40 degrees C protects cells against heat shock-induced apoptosis. Journal of cellular physiology. 2005; 205(1):47-57.

Wrzal PK, Bettaieb A, Averill-Bates DA. Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiation research. 2008; 170(4):498-511.

Bettaieb A, Averill-Bates DA. Thermotolerance induced at a fever temperature of 40 degrees C protects cells against hyperthermia-induced apoptosis mediated by death receptor signaling. Biochemistry and cell biology. 2008; 86(6):521-38.

Roy J, Pallepati P, Bettaieb A, Tanel A, Averill-Bates DA. Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chemico-biological interactions. 2009; 181(2):154-67.

Roy J, Pallepati P, Bettaieb A, Averill-Bates DA. Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. Canadian journal of physiology and pharmacology. 2010; 88(3):353-68.

Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Xi Y, Araki K, Yang W, Kahn BB, Neel BG, Haj FG. Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. The Journal of biological chemistry. 2010; 285(51):39750-8.

Matsuo K*, Bettaieb A*, Nagata N, Matsuo I, Keilhack H, Haj FG. Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. PloS one. 2011; 6(1):e16446.

Bettaieb A*, Liu S*, Xi Y, Nagata N, Matsuo K, Matsuo I, Chahed S$, Bakke J$, Keilhack H, Tiganis T, Haj FG. Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. The Journal of biological chemistry. 2011; 286(11):9225-35.

Luria A*, Bettaieb A*, Xi Y, Shieh GJ, Liu HC, Inoue H, Tsai HJ, Imig JD, Haj FG, Hammock BD. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(22):9038-43.

Bettaieb A, Matsuo K, Matsuo I, Nagata N, Chahed S$, Liu S, Haj FG. Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis. Metabolism: clinical and experimental. 2011; 60(8):1193-201.

Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG, Havel PJ. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(35):14670-5.

Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R$, Koromilas AE, Haj FG. Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes. PloS one. 2012; 7(4):e34412.

Nagata N, Matsuo K, Bettaieb A, Bakke J$, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012; 153(7):3158-69.

Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(28):11390-5.

Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Kowala M, Haj FG, Chouinard ML, Havel PJ. Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology. 2012; 153(8):3620-32.

 

Vazquez Prieto MA, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Archives of biochemistry and biophysics. 2012; 527(2):113-8.

 

Wang YI, Bettaieb A, Sun C, DeVerse JS, Radecke CE, Mathew S, Edwards CM, Haj FG, AG, Simon SI. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PloS one. 2013; 8(10):e78322.

Contributions to Jointly Authored Works: Research paper by Wang YI, Ahmed Bettaieb, and colleagues. Experiments designed by all authors. Bettaieb performed experimental work for figures 4, 5, and S4-S6. Written by Passerini and Simon. Work completed at the University of California-Davis.

 

Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Disease models & mechanisms. 2013; 6(2):443-56.

 

Bettaieb A, Nagata N, AbouBechara D$, Chahed S$, Morisseau C, Hammock BD, Haj FG. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. The Journal of biological chemistry. 2013; 88(20):14189-99.

 

Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, TG, Adams SH. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.  American journal of physiology. Endocrinology and metabolism. 2013; 304(11):E1175-87.

 

Bettaieb A*, Bakke J*$, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of biological chemistry. 2013; 288(24):17360-71.

 

Bakke J$, Bettaieb A, Nagata N, Matsuo K, Haj FG. Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B. Cell communication and signaling: CCS. 2013; 11:57.

 

Bettaieb A, Chahed S$, Tabet G$, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PloS one. 2014; 9(11):e113019.

 

Warden CH, Slupsky C, Griffey SM, Bettaieb A, Min E, Le A, Fisler JS, Hansen S, Haj F, Stern JS. Brown Norway chromosome 1 congenic reduces symptoms of renal disease in fatty Zucker rats. PloS one. 2014; 9(1):e87770.

 

Bettaieb A, Xi Y, Hosein E$, Coggins N$, Bachaalany S$, Wiede F, Perez S, Griffey SM, Sastre J, Tiganis T, Haj FG. Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell communication and signaling: CCS. 2014; 12:13.

 

Cummings BP, Bettaieb A, Graham JL, Stanhope K, Haj FG, Havel PJ. Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats.  The Journal of endocrinology. 2014; 221(1):133-44.

Tanel A, Pallepati P, Bettaieb A, Morin P, Averill-Bates DA. Acrolein activates cell survival and apoptotic death responses involving the endoplasmic reticulum in A549 lung cells. Biochimica et biophysica acta. 2014; 1843(5):827-35.

 

Bettaieb A*, Vazquez Prieto MA*, Rodriguez Lanzi C, Miatello RM, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free radical biology & medicine. 2014; 72:247-56.

 

Liu S, Xi Y, Bettaieb A, Matsuo K, Matsuo I, Kulkarni RN, Haj FG. Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology. 2014; 155(9):3329-38.

 

Bettaieb A, Morisseau C, Hammock B, Haj F. Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice. Free radical biology & medicine. 2014; 75 Suppl 1:S32.

 

Glory A*, Bettaieb A*, Averill-Bates DA. Mild thermotolerance induced at 40°C protects cells against hyperthermia-induced pro-apoptotic changes in Bcl-2 family proteins. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2014; 30(7):502-12.

 

Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging cell. 2014; 13(6):1049-58.

 

Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E$, Chahed S$, Wiede F, Zhang S, Zhang ZY, Kulkarni RN, Tiganis T, Haj FG. Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia. 2015; 58(1):122-31.

 

Bettaieb A, Averill-Bates DA. Thermotolerance induced at a mild temperature of 40°C alleviates heat shock-induced ER stress and apoptosis in HeLa cells. Biochimica et biophysica acta. 2015; 1853(1):52-62.

 

Vazquez Prieto MA*, Bettaieb A*, Rodriguez Lanzi C, Soto VC, Perdicaro DJ, Galmarini CR, Haj FG, Miatello RM, Oteiza PI. Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes. Molecular nutrition & food research. 2015; 59(4):622-33.

 

Jialal I, Devaraj S, Bettaieb A, Haj F, Adams-Huet B. Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome. Atherosclerosis. 2015; 241(1):130-7.

 

Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic eticulum stress induced by carbon tetrachloride in mice. Toxicology and applied pharmacology. 2015; 286(2):102-11.

 

Inceoglu B*, Bettaieb A*, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(29):9082-7.

 

Bettaieb A, Chahed S$, Bachaalany S$, Griffey S, Hammock BD, Haj FG. Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Molecular pharmacology. 2015; 88(2):281-90.

 

Bettaieb A*, Jiang JX*, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ. Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice. Gastroenterology. 2015; 149(2):468-80.e10.

 

McGavigan AK, Garibay D, Henseler ZM, Chen J, Bettaieb A, Haj FG, Ley RE, Chouinard ML, Cummings BP. TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut. 2015; 2015-309871

 

Bettaieb A, Hosein E$, Chahed S$, Abdulaziz A$, Kucera HR, Gaikwad NW, Haj FG. Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity (Silver Spring, Md.). 2015; 23(11):2269-77.

 

Cremonini E*, Bettaieb A*, Haj FG, Fraga CG, Oteiza PI. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Archives of biochemistry and biophysics. 2016; 599:13-21.

 

Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. p46Shc inhibits thiolase and lipid oxidation in mitochondria. The Journal of biological chemistry. 2016; 291(24):12575-85.

 

Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. Molecular mechanisms and new treatment paradigm for atrial fibrillation. circulation. arrhythmia and electrophysiology. 2016; 9(5).

 

Bettaieb A, Koike S$, Chahed S$, Bachaalany S$, Griffey S, Sastre J, Haj FG. Pancreatic protein tyrosine phosphatase 1B deficiency exacerbates acute pancreatitis in mice. The American journal of pathology. 2016; 186(8):2043-54.

 

Bettaieb A*, Cremonini E*, Kang H, Kang J, Haj FG, Oteiza PI. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. The international journal of biochemistry & cell biology. 2016; S1357-2725(16)30261.

 

Johnstone M, Bennett N, Standifer C, Smith A, Han A, Bettaieb A, Whelan J. and Donohoe D. Characterization of the pro-inflammatory cytokine il-1beta on butyrate oxidation in colorectal cancer cells. J Cell Biochem. 2016; 118(6):1614-1621.

 

 

Hsu MF, Bettaieb A, Ito Y, Graham J, Havel PJ, Haj FG. Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep. 2017; 7: 461.

 

Trindade-da-Silva CA*, Bettaieb A*, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, rank-related signaling, endoplasmic reticulum stress, and apoptosis. J Pharmacol Exp Ther. 2017; 361: 408-416

 

Bettaieb A#, Koike S$, Chahed S$, Zhao Y$, Bachaalany S$, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG. Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J. 2017; 284: 1970-1986.

 

Bettaieb A, Koike S$, Hsu MF, Ito Y, Chahed S$, Bachaalany S$, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochimica et biophysica acta. 2017: S0304-4165(17)30238-6.

Inceoglu B*#, Bettaieb A*#, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors, Prostaglandins Other Lipid Mediat. 2017; 133:68-78.

 

Ito Y, Hsu MF, Bettaieb A, Koike S$, Mello A, Calvo-Rubio M, Villalba JM, Haj FG. Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism. 2017; 76:56-69.

 

Warden CH, Bettaieb A, Min E, Fisler JS, Haj FG, Stern JS. Chow fed UC Davis strain female Lepr fatty Zucker rats exhibit mild glucose intolerance, hypertriglyceridemia, and increased urine volume, all reduced by a Brown Norway strain chromosome 1 congenic donor region. PLoS One. 2017; 12(12):e0188175.

 

Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza PI. (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018: 588-599.

 

MacDonald AF, Bettaieb A, Donohoe DR, Alani DS$, Han A, Zhao Y$, Whelan J. Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complement Altern Med. 2018; 18(1):188.

 

Han A, Bennett N, Bettaieb A, Whelan J, Donohoe DR. Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases. Oncotarget. 2018; 9(43):27280-27292.

 

Tomilov A, Allen S, Hui CK, Bettaieb A, Cortopassi G. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition. Pharmacol Res. 2018;137:89-103.

 

Alquraishi M$, Puckett DL$, Alani DS$, Humidat AS$, Frankel VD$, Donohoe DR, Whelan J, Bettaieb A Pyruvate kinase M2: a simple molecule with complex functions. Free Radic Biol Med. 2019; 143:176-192. 

 

Puckett D$, Alquraishi M$, Alani D$, Chahed S$, Frankel VD, Donohoe DR, Voy BH, Whelan J, and Bettaieb A. Zyflamend, a Unique Herbal Blend, Inhibits Adipogenesis through the Coordinated Regulation of PKA and JNK. Adipocyte. 2020; 9:1, 454-471

 

Puckett D$, Alquraishi M$, Alani DA$, Chahed S$, Donohoe DR, Voy BH, Whelan J, and Bettaieb A. Zyflamend Induces Apoptosis in Pancreatic Cancer cells via Modulation of the JNK Pathway. Cell Communication and Signaling. 2020; 14;18(1):126.

 

Strong MD,  Hart MD, Z. Tang TZ,  Ojo  BA, Wu  L, Nacke MR,  Agidew WT, Hwang  HJ, Hoyt PR, Bettaieb A.,  Clarke SL, Smith BJ, Stoecker BJ,  Lucas EA, Lin  D, Chowanadisai W. Role of zinc transporter ZIP12 in susceptibility‐weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function. The FASEB Journal. 2020. 2020;34:12702–12725.

 

Overby H, Yang Y, Xu X, Graham K, Hildreth K. Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, and Zhao L. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. 2020. Int J Mol Sci 21(19).

 

Puckett D, Alquraishi M, Chowanadisai W, and Bettaieb A. The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs. 2021. Int J Mol Sci 22(3).

Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, and L. Zhao L. Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice. 2021. Int J Mol Sci 22(15).

 

Davis DN, Strong MD, Chambers E, Hart MD, Bettaieb A, Clarke SL, Smith BJ, Stoecker BJ, Lucas EA, Lin D, Chowanadisai W. A role for zinc transporter gene SLC39A12 in the nervous system and beyond. 2021. Gene 799-145824.

 

Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, and Haj FG. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss, Free radical biology & medicine. 2021. 48-57.